The Effect of Astragalus Extractive on Alveolar Bone Rebuilding Progress of Tooth Extracted Socket of Ovariectomied Rats
Identifieur interne : 000349 ( Main/Exploration ); précédent : 000348; suivant : 000350The Effect of Astragalus Extractive on Alveolar Bone Rebuilding Progress of Tooth Extracted Socket of Ovariectomied Rats
Auteurs : Xiaochen Liu [République populaire de Chine] ; Runju Zhang [République populaire de Chine] ; Yi Zhou [République populaire de Chine] ; Yanli Yang [République populaire de Chine] ; Hongling Si [République populaire de Chine] ; Xiaohong Li [République populaire de Chine] ; Li Liu [République populaire de Chine]Source :
- African Journal of Traditional, Complementary, and Alternative Medicines [ 0189-6016 ] ; 2014.
Abstract
Postmenopausal osteoporosis (PMO) is an estrogen deficiency condition that causes severe loss of bone mass in the vertebrae and long bones. We explored the effect and the possible underlying mechanism of the extracts of
The PMO models were acquired by ovariectomy. After 8 weeks the first left maxillary molars of the rats were extracted and AE was administered orally for 8 weeks. Then the histological morphology and the transcription and expression of TGF-β1 and TNF-α in the tooth extracted socket were detected by HE dying, QRT-PCR and ELISA.
The results showed that the new bone volume and TGF-β1 was significantly lower in PMO group than the control group and AE group at the observing period. At the same time TNF-α in PMO group was significantly higher than the other two groups. Moreover AE group had no significant differences with the control group in all data at the observing period.
AE has positive effect on alveolar bone rebuilding progress of tooth extracted socket of PMO rats. AE also has the potential to enhance the expression of TGF-β1 and decrease the expression of TNF-α of the rebuilding tooth extracted socket.
Url:
PubMed: 25395711
PubMed Central: 4202524
Affiliations:
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Hangzhou, Zhejiang</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Runju" sort="Zhang, Runju" uniqKey="Zhang R" first="Runju" last="Zhang">Runju Zhang</name><affiliation wicri:level="4"><nlm:aff id="A2">Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhou, Yi" sort="Zhou, Yi" uniqKey="Zhou Y" first="Yi" last="Zhou">Yi Zhou</name><affiliation wicri:level="4"><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Yang, Yanli" sort="Yang, Yanli" uniqKey="Yang Y" first="Yanli" last="Yang">Yanli Yang</name><affiliation wicri:level="4"><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Si, Hongling" sort="Si, Hongling" uniqKey="Si H" first="Hongling" last="Si">Hongling Si</name><affiliation wicri:level="1"><nlm:aff id="A3">Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiaohong" sort="Li, Xiaohong" uniqKey="Li X" first="Xiaohong" last="Li">Xiaohong Li</name><affiliation wicri:level="1"><nlm:aff id="A3">Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><affiliation wicri:level="4"><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><series><title level="j">African Journal of Traditional, Complementary, and Alternative Medicines</title><idno type="eISSN">0189-6016</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Postmenopausal osteoporosis (PMO) is an estrogen deficiency condition that causes severe loss of bone mass in the vertebrae and long bones. We explored the effect and the possible underlying mechanism of the extracts of <italic>Astragalus</italic> (AE) on the tooth alveolar bone rebuilding progress of postmenopausal osteoporosis of PMO animal models.</p></sec><sec sec-type="materials|methods"><title>Material and methods</title><p>The PMO models were acquired by ovariectomy. After 8 weeks the first left maxillary molars of the rats were extracted and AE was administered orally for 8 weeks. Then the histological morphology and the transcription and expression of TGF-β1 and TNF-α in the tooth extracted socket were detected by HE dying, QRT-PCR and ELISA.</p></sec><sec sec-type="results"><title>Results</title><p>The results showed that the new bone volume and TGF-β1 was significantly lower in PMO group than the control group and AE group at the observing period. At the same time TNF-α in PMO group was significantly higher than the other two groups. Moreover AE group had no significant differences with the control group in all data at the observing period.</p></sec><sec sec-type="conclusion"><title>Conclusion</title><p>AE has positive effect on alveolar bone rebuilding progress of tooth extracted socket of PMO rats. AE also has the potential to enhance the expression of TGF-β1 and decrease the expression of TNF-α of the rebuilding tooth extracted socket.</p></sec></div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Liu, Xiaochen" sort="Liu, Xiaochen" uniqKey="Liu X" first="Xiaochen" last="Liu">Xiaochen Liu</name></region><name sortKey="Li, Xiaohong" sort="Li, Xiaohong" uniqKey="Li X" first="Xiaohong" last="Li">Xiaohong Li</name><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><name sortKey="Si, Hongling" sort="Si, Hongling" uniqKey="Si H" first="Hongling" last="Si">Hongling Si</name><name sortKey="Yang, Yanli" sort="Yang, Yanli" uniqKey="Yang Y" first="Yanli" last="Yang">Yanli Yang</name><name sortKey="Zhang, Runju" sort="Zhang, Runju" uniqKey="Zhang R" first="Runju" last="Zhang">Runju Zhang</name><name sortKey="Zhou, Yi" sort="Zhou, Yi" uniqKey="Zhou Y" first="Yi" last="Zhou">Yi Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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